Pain is the most frequent symptom for patients with knee osteoarthritis. The pain from knee arthritis is usually described as being in the front or sides of the knee. The pain is frequently worsened with activity and relieved by rest. It may occur at night and, in severe cases, prevent sleep. Patients with knee arthritis also tend to have stiffness and often limp when they walk. They may have difficulty going up and down stairs and walking long distances.